Inhaled voriconazole for prevention of invasive pulmonary aspergillosis.
نویسندگان
چکیده
Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.
منابع مشابه
Remarkably efficient inhaled antifungal monotherapy for invasive pulmonary aspergillosis.
Voriconazole is a broad-spectrum antifungal agent that is effective against moulds such as Aspergillus fumigatus. It inhibits the cytochrome P450-dependent 14-a–lanosterol demethylase, preventing the conversion of lanosterol to ergosterol. This results in the accumulation of toxic methylsterols in the fungal wall and the inhibition of fungal growth [1]. Voriconazole is available as an intraveno...
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nazole for prevention of invasive pulmonary aspergillosis. Antimicrob Agents Chemother 2009; 53: 2613–2615. 4 Tolman JA, Nelson NA, Son YJ, et al. Characterization and pharmacokinetic analysis of aerosolized aqueous voriconazole solution. Eur J Pharm Biopharm 2009; 72: 199–205. 5 Crandon JL, Banevicius MA, Fang AF, et al. Bronchopulmonary disposition of intravenous voriconazole and anidulafungi...
متن کاملProphylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis.
OBJECTIVES Amphotericin B inhalation powder (ABIP) is a novel dry-powder amphotericin B formulation that is directly delivered to the lung, resulting in elevated lung tissue drug concentrations of this polyene. We evaluated the prophylactic efficacy of single dose administration of ABIP in a guinea pig model of invasive pulmonary aspergillosis. METHODS Guinea pigs were immunosuppressed with c...
متن کاملAccelerated metabolism of voriconazole and its partial reversal by cimetidine.
We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytochrome P450 enzyme inhibitor.
متن کاملVoriconazole for invasive bone aspergillosis: a worldwide experience of 20 cases.
UNLABELLED BACKGROUND; Bone aspergillosis remains a rare but potentially devastating fungal disease. Although voriconazole is effective for invasive pulmonary aspergillosis, evidence of its efficacy for aspergillosis located in bone is limited. METHODS We report our experience with voriconazole in 4 cases of invasive bone aspergillosis. In addition, all cases of probable and definite bone asp...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 53 6 شماره
صفحات -
تاریخ انتشار 2009